Tories



Patented July 19, 1927.

UNITED STATES,

PATENT OFFICE;

ERNEST H. VOLWILEB, OF HIGHLAND PARK, ILLINOIS, ASSIGNOR TO ABBOTT LABOR-- TORIES, OF NORTH QHICAGO, ILLINOIS, A CORPORATION OF ILLINOIS.

ammonia-non) namvl'rrva.

11o Drawing;

My invention relates to the production of derivatives of barbituric acid, having the following general structure,

in which R re resents a butyl group, and X represents hy rogen, a metallic element or an organic base. These compounds exert pronounced hypnotic action, with relatively low, toxicity.

The compounds may be synthesized as fol-- Application filled July 18,1918. Serial I0. 123,011.

n-butyl barbituric acidhave separated. The solid is filtered off, and recrystallized from dilute alcohol or .water. It is obtained as white crystals, melting at 128 (3.; it is only slightly solublein water but readily soluble in alcohol and ether.

I claim as my invention:

1. As' new articles of manufacture, the barbituric acid derivatives H oo-un (fl-i04 A cm==cnon $0-x I where X represents hydrogen, a. metallic element, or an organic base.

2. As a new article of manufacture, the compound n-butyl-allyl-barbituric acid, which exists as white crystals, melting at 128 C.

July 7, 1926.

ERNEST H. VOLWI LER. 

